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Thymus Grafts in Thymectomized and Normal Mice

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Abstract

EXPERIMENTS carried out on cytologically marked normal F1 recipients implanted with a thymus from a newborn donor of the parental type have shown that cellular traffic from the host to the thymus graft can take place1. Using neonatally thymectomized2–4 or thymectomized and irradiated5 recipients it has been possible to show that cells can also migrate from a thymus graft to the peripheral lymphoid tissue and that these may respond mitotically to immunological challenge6,7. In the situations in which thymic repopulation has been investigated in detail, it has always been possible for cells of thymic origin to react against some of the antigens of the F1 host. It is possible that this antigenic difference between the host and thymus graft might affect the repopulation process. In order to investigate this problem CBA/H recipients and cytologically marked CBA/H-T6T6 thymus graft donors have been used. There is no difference between these strains at the histocompatibility loci3. The cytological constitution of (a) the thymus graft at various times after grafting, (b) the spleen 30 days after thymus grafting and (c) the spleen following injection of antigen at 30 days has been determined.

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Authors and Affiliations

  1. Institute of Cancer Research, Royal Cancer Hospital, London

    E. LEUCHARS, A. MORGAN, A. J. S. DAVIES & V. J. WALLIS

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  1. E. LEUCHARS
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  2. A. MORGAN
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  3. A. J. S. DAVIES
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  4. V. J. WALLIS
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LEUCHARS, E., MORGAN, A., DAVIES, A. et al. Thymus Grafts in Thymectomized and Normal Mice. Nature 214, 801–802 (1967). https://doi.org/10.1038/214801a0

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