Skip to main content
SpringerLink
Log in

Regulatory Genes controlling the Synthesis of Heavy Chains of Human Immunoglobulin-G

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

The production of immunoglobulins is controlled by a combination of genes. It appears that most individuals carry genes for both types of immunoglobulin, Gm(a) and Gm(b). Whether or not these genes actually find expression in the phenotype, however, seems to depend on the action of regulatory genes which can control the expression of the cistrons coding for Gm(a) or Gm(b).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Terry, W. D., and Fahey, J. L., Science, 146, 400 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Grey, H. M., and Kunkel, H. G., J. Exp. Med., 120, 253 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Nowell, P. C., Cancer Res., 20, 462 (1960).

    CAS  PubMed  Google Scholar 

  4. Pearmain, G., Lycette, R. R., and Fitzgerald, P. H., Lancet, i, 637 (1963).

  5. Elves, M. W., Roath, S., and Israels, M. C. G., Lancet, i, 806 (1963).

  6. Robbins, J. H., Science, 146, 1648 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Forbes, I. J., and Turner, K. J., Austral. Ann. Med., 14, 304 (1965).

    Article  CAS  Google Scholar 

  8. Turner, K. J., and Forbes, I. J., J. Immunol., 96, 926 (1966).

    CAS  PubMed  Google Scholar 

  9. Bach, F. H., and Hirschhorn, K., Exp. Cell Res., 32, 592 (1963).

    Article  CAS  PubMed  Google Scholar 

  10. Hirschhorn, K., Bach, F. H., Kolodny, R. L., Firschein, I. L., and Hashem, N., Science, 142, 1185 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Elves, M. W., Roath, S., Taylor, G., and Israels, M. C. G., Lancet, i, 1292 (1963).

  12. Parenti, F., Franceschini, P., Forti, G., and Cepellini, R., Biochim. Biophys. Acta, 123, 181 (1966).

    Article  CAS  PubMed  Google Scholar 

  13. Marshall, W. H., thesis, Univ. Melbourne (1966).

  14. Curtain, C. C., and Baumgarten, A., Immunology, 10, 499 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Rubin, A., and Cooper, H. L., Blood, 25, 1014 (1965).

    PubMed  Google Scholar 

  16. Curtain, C. C., Nature, 203, 1380 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Harboe, M., and Lundevall, B., Acta Path. Microbiol. Scand., 45, 357 (1959).

    Article  CAS  PubMed  Google Scholar 

  18. Nossall, G. J. V., Adv. Immunol., 2, 163 (1962).

    Article  Google Scholar 

  19. Kunkel, H. G., Allen, J. C., Grey, H. M., Martensson, L., and Grubb, R., Nature, 203, 413 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Nature, 209, 653 (1966).

Download references

Author information

Author notes

  1. NOELENE LOBB & CHEV KIDSON

    Present address: Department of Molecular Genetics, Institute of Hormone Biology, Syntex Research Center, Palo Alto, California

  2. C. C. CURTAIN

    Present address: C.S.I.R.O. Division of Animal Health, Private Bag No. 1, Parkville, N. 2, Victoria

Authors and Affiliations

  1. Baker Medical Research Institute, Melbourne, S.I, Victoria, Australia

    NOELENE LOBB, C. C. CURTAIN & CHEV KIDSON

Authors
  1. NOELENE LOBB
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. C. CURTAIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. CHEV KIDSON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LOBB, N., CURTAIN, C. & KIDSON, C. Regulatory Genes controlling the Synthesis of Heavy Chains of Human Immunoglobulin-G. Nature 214, 783–785 (1967). https://doi.org/10.1038/214783a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/214783a0

  • Springer Nature Limited

Search

Navigation