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Does the Agent of Scrapie Replicate without Nucleic Acid ?

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Abstract

Scrapie is a slowly developing disease of the nervous system. Experiments on the effects of ultra-violet irradiation of suspensions of infected mouse brain extracts confirm that the agent responsible for it does not depend on a nucleic acid for its ability to replicate. No evidence is obtained, however, to indicate whether the agent is associated with a protein.

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References

  1. Stamp, J. T., Brotherston, J. G., Zlotnik, I., MacKay, J. M. K., and Smith, W., J. Comp. Path., 69, 268 (1959).

    Article  CAS  Google Scholar 

  2. Alper, T., Haig, D. A., and Clarke, M. C., Biochem. Biophys. Res. Commun., 22, 278 (1966).

    Article  CAS  Google Scholar 

  3. Eklund, C. M., Kennedy, R. C., and Hadlow, W. J., J. Infect. Dis., 117, 15 (1967).

    Article  CAS  Google Scholar 

  4. Haig, D. A., and Clarke, M. C., in Slow, Latent and Temperate Virus Infections, NINDB, Monograph No. 5 (edit. by Gajdnsek, D. C., Gibbs, C. J., and Alpers, M.) (Washington, 1965).

    Google Scholar 

  5. Pattison, I. H., and Jones, K. M., Vet. Rec., 80, 2 (1967).

    Article  CAS  Google Scholar 

  6. Magnus, I. A., Porter, A. D., McCree, K. J., Moreland, J. D., and Wright, W. D., Brit. J. Dermatol., 71, 261 (1959).

    Article  CAS  Google Scholar 

  7. Parker, C. A., Proc. Roy. Soc., A, 220, 104 (1953).

    Article  ADS  CAS  Google Scholar 

  8. Sztumpf-Kulikowska, E., Shugar, D., and Boag, J. W., Photochem. Photobiol., 6, 41 (1967).

    Article  CAS  Google Scholar 

  9. Kärber, G., Arch. Exp. Path. Pharmak., 162, 480 (1931).

    Article  Google Scholar 

  10. Fluke, J. D., and Pollard, E. C., Science, 110, 274 (1949).

    Article  ADS  CAS  Google Scholar 

  11. Kleczkowski, J., and Kleczkowski, A., Photochem. Photobiol., 4, 201 (1965).

    Article  CAS  Google Scholar 

  12. Winkler, U., Photochem. Photobiol., 3, 37 (1964).

    Article  CAS  Google Scholar 

  13. Setlow, J. K., and Duggan, D. E., Biochim. Biophys. Acta, 87, 664 (1964).

    CAS  Google Scholar 

  14. Patrick, M. H., and Rupert, C. S., Photochem. Photobiol., 6, 1 (1967).

    Article  CAS  Google Scholar 

  15. Setlow, R. B., in Mammalian Cytogenetics and Related Problems in Radiobiology, 291 (Pergamon Press, London, 1964).

    Book  Google Scholar 

  16. Setlow, R., and Doyle, B., Biochim. Biophys. Acta, 24, 27 (1957).

    Article  CAS  Google Scholar 

  17. Pattison, I. H., J. Comp. Path., 75, 159 (1965).

    Article  CAS  Google Scholar 

  18. Field, E. J., Brit. Med. J., ii, 546 (1966).

  19. Hadlow, W. J., Lancet, ii, 289 (1959).

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ALPER, T., CRAMP, W., HAIG, D. et al. Does the Agent of Scrapie Replicate without Nucleic Acid ?. Nature 214, 764–766 (1967). https://doi.org/10.1038/214764a0

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