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Chlortetracycline and Mouse Intestinal Wall

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Abstract

Chlortetracycline caused dramatic increases in intestinal weight of bacteria-laden and germ-free female mice only, the greatest in the former. Intestinal histamine and serotonin decreased in all mice except bacteria-laden females which showed increases in serotonin. Thus, sex and microbial status could be important in connexion with tetracycline intoxication.

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Authors and Affiliations

  1. Department of Germfree Research, Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington

    HYMAN ROSEN, ALBERT EINHEBER, NESBITT D. BROWN & ROBERT E. WREN

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  1. HYMAN ROSEN
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  2. ALBERT EINHEBER
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  3. NESBITT D. BROWN
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  4. ROBERT E. WREN
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ROSEN, H., EINHEBER, A., BROWN, N. et al. Chlortetracycline and Mouse Intestinal Wall. Nature 214, 671–674 (1967). https://doi.org/10.1038/214671a0

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