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Structure of Antibody Molecules

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Abstract

Antibody molecules, or “immunoglobulins”, have been recognized only in vertebrates and all are found to have a fundamentally similar structure consisting of two heavy and two light peptide chains. Recent studies of the amino-acid sequences of these chains are of interest in relation to the chemical basis of antibody specificity, the evolution of immunoglobulins and the genetic control of antibody synthesis.

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References

  1. Porter, R. R., in Basic Problems of Neoplastic Disease (edit. by Gellhorn, A., and Hirschberg, E.), 177 (Columbia University Press, New York, 1962).

    Google Scholar 

  2. Noelken, M. E., Nelson, C. A., Buckley, E. C., and Tanford, C., J. Biol. Chem., 240, 218 (1965).

    CAS  PubMed  Google Scholar 

  3. Feinstein, A., and Rowe, A. J., Nature, 205, 147 (1965).

    Article  ADS  CAS  Google Scholar 

  4. Valentine, R. C., and Green, M., J. Mol. Biol. (in the press).

  5. Ishizaka, K., Ishizaka, T., and Lee, E. H., J. Allergy, 37, 336 (1966).

    Article  CAS  Google Scholar 

  6. Milstein, C., Clegg, J. B., and Jarvis, J. M., Nature (in the press).

  7. Gray, W., Dreyer, W., and Hood, L., Science, 155, 465 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Hood, L., Gray, W., and Dreyer, W., J. Mol. Biol., 22, 179 (1966); Proc. U.S. Nat. Acad. Sci., 55, 826, 1966).

    Article  CAS  Google Scholar 

  9. Milstein, C., Proc. Roy. Soc., B, 166, 138 (1966).

    ADS  CAS  Google Scholar 

  10. Baglioni, C., and Cioli, D., J. Exp. Med., 124, 307 (1966).

    Article  CAS  Google Scholar 

  11. Cohen, S., and Gordon, S., Biochem. J., 97, 460 (1965).

    Article  CAS  Google Scholar 

  12. Porter, R. R., Biochem. J., 73, 119 (1959).

    Article  CAS  Google Scholar 

  13. Frangione, B., and Franklin, E. C., J. Exp. Med., 122, 1 (1965).

    Article  CAS  Google Scholar 

  14. Prahl, J. W., Proc. Roy. Soc., B, 166, 108 (1966).

    Google Scholar 

  15. Press, E. M., Piggott, P. J., and Porter, R. R., Biochem. J., 99, 356 (1966).

    Article  CAS  Google Scholar 

  16. Weir, R. C., Porter, R. R., and Givol, D., Nature, 212, 205 (1966).

    Article  ADS  CAS  Google Scholar 

  17. Hill, R. L., Delaney, R., Fellows, R. E., and Lebovitz, H. E., Proc. U.S. Nat. Acad. Sci., 56, 1762 (1966).

    Article  ADS  CAS  Google Scholar 

  18. Haber, E., Proc. U.S. Nat. Acad. Sci., 52, 1099 (1964).

    Article  ADS  CAS  Google Scholar 

  19. Whitney, P. L., and Tanford, C., J. Biol. Chem., 240, 4271 (1965).

    CAS  PubMed  Google Scholar 

  20. Oudin, J., J. Cell Physiol., 67, 77 (1966).

    Article  Google Scholar 

  21. Steinberg, A. G., in Symposium on Human Genetics (edit. by Greenwalt, T. J.) (Lippincott, Philadelphia, 1966).

    Google Scholar 

  22. Beutler, E., Cold Spr. Harb. Symp. Quant. Biol., 29, 261 (1964).

    Article  CAS  Google Scholar 

  23. Gell, P. G. H., and Sell, S., J. Exp. Med., 122, 813 (1965).

    Article  CAS  Google Scholar 

  24. Grey, H. M., and Mannik, M., J. Exp. Med., 122, 619 (1965).

    Article  CAS  Google Scholar 

  25. Gordon, S., and Cohen, S., Immunology, 10, 549 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Gell, P. G. H., and Kelus, A. S., Adv. Immunol., 6 (in the press).

  27. Marchiolanis, J., and Edelman, G. M., Science, 154, 1567 (1966).

    Article  ADS  Google Scholar 

  28. Singer, S. J., and Doolittle, R. F., Science, 153, 13 (1966).

    Article  ADS  CAS  Google Scholar 

  29. Piggott, P. J., and Press, E. M., Biochem. J. (in the press).

  30. Edelman, G. M., and Gally, J. A., Proc. U.S. Nat. Acad. Sci., 57, 353 (1967).

    Article  ADS  CAS  Google Scholar 

  31. Dreyer, W. J., and Bennett, C. J., Proc. U.S. Nat. Acad. Sci., 54, 864 (1965).

    Article  ADS  CAS  Google Scholar 

  32. Shapiro, A. L., Scharff, M. D., Maizel, J. V., and Uhr, J. W., Proc. U.S. Nat. Acad. Sci., 56, 216 (1966).

    Article  ADS  CAS  Google Scholar 

  33. Williamson, A. R., and Askonas, B. A., J. Mol. Biol., 23, 201 (1967).

    Article  CAS  Google Scholar 

  34. La Via, M. F., and Vatter, A. E., Proc. U.S. Nat. Acad. Sci., 57, 79 (1967).

    Article  ADS  CAS  Google Scholar 

  35. Litwin, S. D., and Kunkel, H. G., Nature, 210, 866 (1966).

    Article  ADS  CAS  Google Scholar 

  36. Smithies, O., Science, 149, 151 (1965).

    Article  ADS  CAS  Google Scholar 

  37. Potter, M., Appella, E., and Geisser, S., J. Mol. Biol., 14, 361 (1965).

    Article  CAS  Google Scholar 

  38. Brenner, S., and Milstein, C., Nature, 211, 242 (1966).

    Article  ADS  CAS  Google Scholar 

  39. Hilschmann, N., Rep. of the Eleventh Cong. of the Intern. Soc. of Haematology and Blood Transfusion (in the press) (1966).

  40. Milstein, C., Biochem. J., 101, 351 (1966).

    Google Scholar 

  41. Lennox, E. S., and Cohn, M., Ann. Rev. Biochem. (in the press).

  42. Symposium organized by Porter, R. R., Proc. Roy. Soc., B, 166, 113 (1966).

    Google Scholar 

  43. Cohen, S., and Milstein, C., Adv. Immunol., 7 (in the press).

  44. Brenner, S., and Milstein, C. (unpublished).

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Authors and Affiliations

  1. Department of Chemical Pathology, Guy's Hospital Medical School, London, S.E.I

    S. COHEN

  2. M.R.C. Laboratory of Molecular Biology, Cambridge

    C. MILSTEIN

Authors
  1. S. COHEN
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  2. C. MILSTEIN
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COHEN, S., MILSTEIN, C. Structure of Antibody Molecules. Nature 214, 449–452 (1967). https://doi.org/10.1038/214449a0

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