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Binding of Tetracycline to Mammalian Spermatozoa

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Abstract

TETRACYCLINES are distributed to various body tissues1, which includes human prostatic fluid2,3 and semen3. Oxytetracycline has been used as a fluorescent stain for condensed spermatid nuclei of the rat4. Tetracycline HCl is a known fluorophor, and so we designed in vitro and in vivo experiments to determine, by fluorescent microscopy, whether this antibiotic binds to spermatozoa.

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Authors and Affiliations

  1. Biochemical Research, The Upjohn Company, Kalamazoo, Michigan

    R. J. ERICSSON & V. F. BAKER

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  1. R. J. ERICSSON
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  2. V. F. BAKER
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ERICSSON, R., BAKER, V. Binding of Tetracycline to Mammalian Spermatozoa. Nature 214, 403–404 (1967). https://doi.org/10.1038/214403a0

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