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Increased Tolerance to Posthaemorrhagic Shock in Dogs treated with Reserpine

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Abstract

THE mechanism governing the development and consequences of posthaemorrhagic circulatory collapse has been tentatively related to the activation of the sympathetico-adrenal system. During an early reversible stage after haemorrhage, this activation leads to compensatory readjustments; in a later irreversible stage the persisting sympathetico-adrenal activity brings about vascular and tissue lesions, especially at sites exposed to prolonged vasoconstriction. At this stage the situation cannot be remedied by restoring the blood volume.

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Authors and Affiliations

  1. Istituto di Farmacologia Medica, Universitá di Roma, Rome, Italy

    L. ANGELUCCI & MIRELLA BALDIERI

  2. Centro Studi e Ricerche di Medicina Militare, Rome, Italy

    M. BUONERBA

Authors
  1. L. ANGELUCCI
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  2. MIRELLA BALDIERI
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  3. M. BUONERBA
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ANGELUCCI, L., BALDIERI, M. & BUONERBA, M. Increased Tolerance to Posthaemorrhagic Shock in Dogs treated with Reserpine. Nature 214, 202–203 (1967). https://doi.org/10.1038/214202a0

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  • DOI: https://doi.org/10.1038/214202a0

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