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Metronidazole and Human Alcohol Dehydrogenase

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Abstract

RECENTLY, metronidazole (‘Flagyl’) has been used in the treatment of alcoholism1 and it has been suggested that it might inhibit alcohol dehydrogenase2. We wish to present evidence to shed light on this suggestion.

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References

  1. Taylor, J. A. T., Bull. Los Angeles Neurolog. Soc., 29, 158 (1964).

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  2. Metronidazole in Alcoholism. Preliminary Information for Clinical Investigators (second edition) (May and Baker Ltd., 1966).

  3. von Wartburg, J. P., Papenberg, J., and Aebi, H., Canad. J. Biochem., 43, 889 (1965).

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  4. Kane, P. O., McFadzean, J. A., Squires, S., King, A. J., and Nicol, C. S., Brit. J. Vener. Dis., 37, 273 (1961).

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Author notes

  1. J. PRICE: Bates Research Fellow, Mental Health Research Fund.

Authors and Affiliations

  1. Nuffield Unit of Medical Genetics, Department of Medicine, University of Liverpool,

    J. A. EDWARDS & J. PRICE

Authors
  1. J. A. EDWARDS
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  2. J. PRICE
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EDWARDS, J., PRICE, J. Metronidazole and Human Alcohol Dehydrogenase. Nature 214, 190–191 (1967). https://doi.org/10.1038/214190b0

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