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Cytological Demonstration of Carboxyhaemoglobin in Human Erythrocytes

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Abstract

ALTHOUGH oxyhaemoglobin is oxidized by nitrite to methaemoglobin, carboxyhaemoglobin is not. This difference can be used to demonstrate the presence of carboxyhaemoglobin in single erythrocytes of a blood smear, simply by extending the methaemoglobin- (cyanmethaemoglobin-) elution technique of Kleihauer and Betke1.

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References

  1. Kleihauer, E., and Betke, K., Nature, 199, 1196 (1963).

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Authors and Affiliations

  1. Universitätskinderklinik, Tübingen, Germany

    KLAUS BETKE & ENNO KLEIHAUER

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  1. KLAUS BETKE
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  2. ENNO KLEIHAUER
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BETKE, K., KLEIHAUER, E. Cytological Demonstration of Carboxyhaemoglobin in Human Erythrocytes. Nature 214, 188–189 (1967). https://doi.org/10.1038/214188a0

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