Abstract
NUMEROUS investigators have reported the effects of neonatal thymectomy on immunological responses1–4. Immunological competence has been restored by implanting thymic grafts1, by inserting a cell tight chamber containing thymus into the intraperitoneal cavity of the thymectomized animal5,6 by injecting whole cells from spleen or thymus7 and by injecting a cell free extract of thymus8. None of these methods provided unequivocal evidence for the cellular origin of the active factor from thymus.
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BRUNKHORST, W., HERRANEN, A. Effects of Extracts from Thymus on Homograft Survival in Rats. Nature 214, 181–183 (1967). https://doi.org/10.1038/214181b0
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DOI: https://doi.org/10.1038/214181b0
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