Skip to main content
Log in

Tertiary Structure of Ribonuclease

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

A model is proposed of the polypeptide chain in bovine pancreatic ribonuclease based on a 2 Å electron density map involving 7,294 reflexions and data from seven heavy atom derivatives. The molecule seems to be roughly kidney shaped with dimensions of about 38 × 28 × 22 Å with a deep depression in the middle of one side. The model disagrees with that based on a 5.5 Å map suggested by Dr. C. H. Carlisle et al. (Nature, 213, 557; 1967).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Smyth, D. G., Stein, W. H., and Moore, S., J. Biol. Chem., 238 (1963).

  2. Anfinsen, C. B., Brookhaven Symp. Enzyme Models and Enzyme Structure, 184 (1962).

  3. Furnas, T. C., Harker, D., Rev. Sci. Instrum., 26, 449 (1955).

    Article  CAS  ADS  Google Scholar 

  4. Harker, D., Acta Cryst., 9 (1956).

  5. Kendrew, J. C., Dickerson, R. E., Strandberg, B. E., Hart, R. G., Davies, D. R., Phillips, D. C., and Shore, V. C., Nature, 185, 422 (1960).

    Article  CAS  ADS  Google Scholar 

  6. Blake, C. C. F., Koenig, D. F., Mair, G. A., North, A. C. T., Phillips, D. C., and Sarma, V. R., Nature, 206, 757 (1965).

    Article  CAS  ADS  Google Scholar 

  7. Kartha, G., Bello, J., Harker, D., and DeJarnette, F. E., Aspects of Protein Structure, 13 (Academic Press, New York, 1963).

    Google Scholar 

  8. Kartha, G., and Parthasarathy, R., Acta Cryst., 18, 745, 749 (1965).

    Article  CAS  Google Scholar 

  9. Kartha, G., Acta Cryst., 19, 883 (1965).

    Article  CAS  Google Scholar 

  10. Mathews, B. W., Acta Cryst., 20, 82, 230 (1965).

    Article  Google Scholar 

  11. Kartha, G., Amer Cryst. Assoc. Meet. Boseman, July, 1964.

  12. North, A. C. T., Acta Cryst., 18, 212 (1965).

    Article  CAS  Google Scholar 

  13. Barnard, E. A., and Stein, W. D., Biochim. Biophys. Acta, 37, 371 (1960).

    Article  CAS  Google Scholar 

  14. Stark, G. R., Stein, W. H., and Moore, S., J. Biol. Chem., 236, 436 (1961).

    CAS  Google Scholar 

  15. Richards, F. M., and Vithayathil, P. J., Brookhaven Symp. in Molecular Biology, 13, 115 (1960).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

KARTHA, G., BELLO, J. & HARKER, D. Tertiary Structure of Ribonuclease. Nature 213, 862–865 (1967). https://doi.org/10.1038/213862a0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/213862a0

  • Springer Nature Limited

This article is cited by

Navigation