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Enhanced Muscle Regeneration and Increased Strength in Myopathic Animals treated with Ethylenedinitramine

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Abstract

DIFFERENTIATION of skeletal muscle is activated as a function of replication1. This predicts that enhancement of growth in a myogenic system will increase the yield in new muscle. Excessive proliferation, however, can cancel muscle differentiation2. In employing the theory it is therefore necessary to stipulate that increased growth shall not reach deleterious levels (although just what these levels are cannot yet be specified). The properties of ethylenedinitramine (EDNA)3,4 seemed, intuitively, to satisfy this condition. EDNA enhanced the regeneration of muscle under several specific conditions.

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Authors and Affiliations

  1. Biochemical Research Laboratory, The Dow Chemical Company, Midland, Michigan

    PAUL PIETSCH & JOHN HARROLD

Authors
  1. PAUL PIETSCH
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  2. JOHN HARROLD
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PIETSCH, P., HARROLD, J. Enhanced Muscle Regeneration and Increased Strength in Myopathic Animals treated with Ethylenedinitramine. Nature 213, 601–603 (1967). https://doi.org/10.1038/213601a0

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