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Effect of Botulinum Toxin on Autonomic Nerves in a Dually Innervated Tissue

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Abstract

A HYPOTHESIS has suggested the existence of a cholinergic link in adrenergic transmission of postganglionic sympathetic nerve endings1. Much evidence has been presented in support of this hypothesis2,3. Botulinum toxin has been said to block sympathetic nerve transmission4. Botulinum toxin is known to block the release of acetylcholine from classically cholinergic nerve fibres5,6, and so it was suggested that sympathetic impairment by botulinum toxin reflects an action on the hypothetical cholinergic link in the sympathetic nerve fibre ending. Rather large concentrations of the toxin (20,000 to 50,000 L.D.50/ ml.) and long times (2–5 h) were, however, necessary to produce sympathetic blockage. It was therefore desirable to test the action of botulinum toxin on a dually innervated tissue so that effects on both classically adrenergic sympathetic fibres and classically cholinergic parasym-pathetic fibres could be observed in the same preparation.

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Author notes

  1. FRANK F. VINCENZI

    Present address: Department of Pharmacology, University of Berne, Berne, Switzerland

Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington

    FRANK F. VINCENZI

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  1. FRANK F. VINCENZI
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VINCENZI, F. Effect of Botulinum Toxin on Autonomic Nerves in a Dually Innervated Tissue. Nature 213, 394–395 (1967). https://doi.org/10.1038/213394a0

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