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Effect on the Infectivity of Various Viruses by the Intestinal Factor of Normal Mice which inactivates Murine Hepatitis Virus

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Abstract

THE capability of the intestine of normal mice to inactivate murine hepatitis virus (MHV-3) (ref. 1) has been reported2. The inactivating factor is present mainly in the first section of the mucosa of the small intestine of the adult mouse3; it is present in the intestine of germ-free mice4, and its interaction with the virus in vitro is dependent on temperature and incubation time3. The factor is inactivated at 70° C for 10 min, is not dialysable and is not present in acetone-dried powders of mouse intestine5. The present paper deals with the effect of the partially purified inhibiting factor on the infectivity of several viruses.

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References

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Authors and Affiliations

  1. Institute of Infectious Diseases, University of Naples, Via Cotugno 1

    M. PIAZZA & G. PANE

  2. Istituto Sieroterapico Italiano, Via S. Giacomo dei Capri 66, Naples

    L. PICCIOTTO & D. LOMBARDI

Authors
  1. M. PIAZZA
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  2. G. PANE
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  3. L. PICCIOTTO
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  4. D. LOMBARDI
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PIAZZA, M., PANE, G., PICCIOTTO, L. et al. Effect on the Infectivity of Various Viruses by the Intestinal Factor of Normal Mice which inactivates Murine Hepatitis Virus. Nature 213, 293–294 (1967). https://doi.org/10.1038/213293a0

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