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Absorption of Exogenous and Endogenous Biliary Copper in the Rat

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Abstract

THE daily intake of copper in man exceeds normal requirements1, but abnormally high body stores have only been recorded in Wilson's disease2,3. Knowledge of the exact mechanism of the absorption of dietary copper is incomplete4 and even less is known about the absorption of endogenous biliary copper or its entero-hepatic circulation4,5. This report concerns the relative intestinal absorption of exogenous copper-64 in two chemical forms (ionic cupric acetate and chelated copper (II-EDTA)) and the absorption of endogenous biliary copper and caeruloplasmin copper.

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References

  1. Wilson's Disease: Some Current Concepts, 9 (edit. by Walshe, J. M., and Cumings, J. N.), (Blackwell, Oxford, 1961).

  2. Scheinberg, I. H., and Sternlieb, I., Gastroenterology, 37, 550 (1959).

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  3. Bickel, H., Neale, F. C., and Hall, G., Quart. J. Med., 26, 527 (1957).

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  4. Adelstein, S. T., and Vallee, B. L., New England J. Med., 265, 892 (1961).

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  5. Crampton, R. F., Mathews, D. M., and Poisner, R., J. Physiol., 178, 111 (1965).

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  6. Farrer, P., and Mistilis, S. P., Proc. of the Third World Congress of Gastro-enterology, Tokyo, 1965 (in the press).

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Authors and Affiliations

  1. Department of Medicine, University of Sydney, Sydney

    P. FARRER

  2. The A. W. Morrow Department of Gastroenterology, Royal Prince Alfred Hospital, Sydney

    S. P. MISTILIS

Authors
  1. P. FARRER
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  2. S. P. MISTILIS
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FARRER, P., MISTILIS, S. Absorption of Exogenous and Endogenous Biliary Copper in the Rat. Nature 213, 291–292 (1967). https://doi.org/10.1038/213291b0

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