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Dependence of Uptake of Succinate by Mitochondria on Energy and its Relation to Potassium Retention

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Abstract

A LONG standing problem in mitochondrial metabolism is the origin of the inhibition of oxidation of anionic substrates which sets in on adding an excess of any agent which uncouples oxidative phosphorylation. It has been noted that the inhibition is moved to higher uncoupler concentrations when the substrate concentration is raised1. This suggests that for some reason the permeation of substrate fails to keep up with the metabolic demand in presence of excess uncoupler. This supposition accords with observations that the respiratory carriers are left in an oxidized condition when inhibition supervenes2.

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References

  1. Wenner, C., Fed. Proc., 24, 554 (1965).

    Google Scholar 

  2. Chance, B., Williams, G. R., and Hollunger, G., J. Biol. Chem., 278, 439 (1963).

    Google Scholar 

  3. Graven, S. N., Estrada-O., and Lardy, H. A., Proc. U.S. Nat. Acad. Sci., 56, 754 (1966).

    Article  Google Scholar 

  4. Pressman, B. C., Methods in Enzymology, 10 (in the press).

  5. Werkheiser, W. C., and Bartley, W., Biochem. J., 66, 79 (1957).

    Article  CAS  Google Scholar 

  6. Klingenberg, M., Pfaff, E., and Kröger, A., in Rapid Mixing and Sampling Techniques in Biochemistry (edit. by Chance, B.) (Academic Press, N.Y., 1964).

    Google Scholar 

  7. Lynn, W. S., and Brown, R. H., Arch. Biochem. Biophys., 114, 260 (1966).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Johnson Research Foundation, University of Pennsylvania, Philadelphia

    E. J. HARRIS, K. VAN DAM & B. C. PRESSMAN

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  1. E. J. HARRIS
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  2. K. VAN DAM
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  3. B. C. PRESSMAN
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HARRIS, E., VAN DAM, K. & PRESSMAN, B. Dependence of Uptake of Succinate by Mitochondria on Energy and its Relation to Potassium Retention. Nature 213, 1126–1127 (1967). https://doi.org/10.1038/2131126a0

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