Abstract
IONIZING radiation produces mutations in a wide variety of living organisms, but its effectiveness as a mutagenic agent for extracellular virus particles is uncertain1–4. We investigated the mutagenic effects of ionizing radiation on free virus particles using the sensitive screening system provided by rII mutants of bacteriophage T4 (ref. 5). In this report, results will be described which show that r+II reverse mutations in T4B rII phage can be induced by X-irradiation of aqueous suspensions of the phage.
Similar content being viewed by others
References
Mundry, K. W., Z. induktive Abstammungs-u. Vererbungslehre, 88, 115 (1957).
Kaplan, R. W., Winkler, U., and Wolf-Ellmauer, H., Nature, 186, 330 (1960).
Van der Ent, G. M., Blok, J., and Linckens, E. M., Mut. Res., 2, 197 (1965).
Ardashnikov, S. N., Soyfer, V. N., and Goldfarb, D. M., Biochem. Biophys. Res. Commun., 16, 455 (1964).
Benzer, S., Proc. U.S. Nat. Acad. Sci., 41, 344 (1955).
Doermann, A. H., J. Bacteriol., 55, 257 (1948).
Steinberg, C. M., and Edgar, R. S., Genetics, 47, 187 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BROWN, D. X-ray-induced Mutations in Extracellular Phage. Nature 212, 1595–1596 (1966). https://doi.org/10.1038/2121595a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/2121595a0
- Springer Nature Limited