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Heterogeneity of Rabbit Serum Interferons

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Abstract

THERE is evidence that, in the rabbit, virus-induced interferon (VII) is induced differently from endotoxin-induced interferon (EII). The induction of VII is inhibited by actinomycin D (ref. 1) and by puromycin2, while the induction of EII is not. Furthermore, Hallum et al.3 demonstrated that, in the mouse, the molecular weight of EII is greater than that of VII. In view of these differences between EII and VII, we decided to study the molecular sizes of rabbit serum interferons induced by virus and by endotoxin.

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References

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Authors and Affiliations

  1. Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

    YANG H. KE & MONTO HO

  2. Department of Medicine, Stanford University School of Medicine, Palo Alto, California

    THOMAS C. MERIGAN

Authors
  1. YANG H. KE
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  2. MONTO HO
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  3. THOMAS C. MERIGAN
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KE, Y., HO, M. & MERIGAN, T. Heterogeneity of Rabbit Serum Interferons. Nature 211, 541–542 (1966). https://doi.org/10.1038/211541a0

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