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In vivo Complex Formation of Actinomycin D and Deoxyribonucleic Acid

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Abstract

ACTINOMYCIN D (AMD) has been shown to inhibit the ribonucleic acid (RNA)-polymerase activity of bacterial cells. This inhibition is considered, at present, to represent the sole mechanism by which this agent inhibits cell division1. It appears to result from the formation of complexes between the antibiotic and deoxyribonucleic acid (DNA)2. Following parenteral administration to animals the antibiotic appears to possess similar activity, but differs in that high doses are required and the effects are reversible3. When administered to rats which have undergone partial hepatectomy, the expected subsequent mitotic activity can be eliminated4.

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References

  1. Goldberg, I. H., Rabinowitz, M., and Reich, E., Proc. U.S. Nat. Acad. Sci., 48, 2094 (1962).

    Article  ADS  CAS  Google Scholar 

  2. Waring, M. J., Mol. Pharm., 1, 1 (1965).

    CAS  Google Scholar 

  3. Holtzer, R. L., Oda, A., and Chiga, M., Lab. Invest., 13, 1514 (1964).

    CAS  PubMed  Google Scholar 

  4. Fujioka, M., Koga, M., and Lieberman, I., J. Biol. Chem., 238, 3401 (1963).

    CAS  PubMed  Google Scholar 

  5. Higgins, G. M., and Anderson, R. M., Arch. Path., 12, 186 (1931).

    Google Scholar 

  6. Hymer, W. C., and Kuff, E. L., J. Histochem. Cytochem., 12, 360 (1964).

    Article  Google Scholar 

  7. Meselson, M., Stahl, F. W., and Vinograd, J., Proc. U.S. Nat. Acad. Sci., 43, 581 (1957).

    Article  ADS  CAS  Google Scholar 

  8. Nakamoto, T., Fox, C. F., and Weiss, S. B., J. Biol. Chem., 239, 167 (1964).

    CAS  PubMed  Google Scholar 

  9. Gellert, M., Smith, C. E., Neville, D., and Felsenfeld, G., J. Mol Biol., 11, 445 (1965).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Pathology and Environmental Medicine, New York University School of Medicine, New York

    FREDERICK F. BECKER, ANN A. MARGOLIS & WALTER TROLL

Authors
  1. FREDERICK F. BECKER
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  2. ANN A. MARGOLIS
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  3. WALTER TROLL
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BECKER, F., MARGOLIS, A. & TROLL, W. In vivo Complex Formation of Actinomycin D and Deoxyribonucleic Acid. Nature 211, 84–85 (1966). https://doi.org/10.1038/211084a0

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