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Inhibition of Ribonucleic Acid Synthesis in Mouse Skin by Actinomycin D and 7,12-Dimethylbenz[α]anthracene

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Abstract

IT has recently been demonstrated that the initiation of skin tumorigenesis by 7,12-dimethylbenz[α]anthracene (DMBA) is dramatically inhibited by topical applications of actinomycin D1,2. In view of the well-known inhibitory action of actinomycin D on DNA-dependent RNA synthesis3, it was proposed that this observation helps support the hypothesis that the early events of chemical tumorigenesis involve alterations in the expression of specific genetic information. In the present study we describe the effect of topical applications of actinomycin D, of DMBA, and of the two combined on the synthesis of RNA in mouse skin. The experimental conditions employed exactly simulate those used to inhibit tumour formation1.

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Authors and Affiliations

  1. Carcinogenesis Studies Branch, National Cancer Institute, Bethesda, Maryland

    W. G. FLAMM, W. B. COUNTS & M. R. BANERJEE

Authors
  1. W. G. FLAMM
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  2. W. B. COUNTS
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  3. M. R. BANERJEE
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FLAMM, W., COUNTS, W. & BANERJEE, M. Inhibition of Ribonucleic Acid Synthesis in Mouse Skin by Actinomycin D and 7,12-Dimethylbenz[α]anthracene. Nature 210, 541–543 (1966). https://doi.org/10.1038/210541a0

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