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Haemoglobin Variants in a Species of Wild Mice—Peromyscus maniculatus

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Abstract

HAEMOGLOBINS from various strains of mice have been referred to as single (Hbs) or diffuse (Hbd)1–3, according to the appearance of the electrophoretic patterns of the haemoglobin haemolysates. Popp1 has suggested that two allelic genes are responsible for the single or double (diffuse) bands. Recently, two investigators4,5 have shown independently that the diffuse patterns are the result of polymerization of mouse haemoglobins to eight-chain double molecules, and hence from 4S to 7S tetramers. This transformation can be enhanced by reduced glutathione (GSH) or oxidized glutathione (GSSG) and inhibited by iodoacetamide (IOA). These polymerization products, frequently encountered with inbred strains and with domestic mice (Mus musculus), are not often found with wild species.

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Authors and Affiliations

  1. Department of Clinical Laboratory Sciences, University of Mississippi, Jackson, Mississippi

    ROBERT B. THOMPSON, H. B. HEWETT, S. S. KILGORE, A. P. SHEPHERD & W. N. BELL

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  1. ROBERT B. THOMPSON
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  2. H. B. HEWETT
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  3. S. S. KILGORE
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  4. A. P. SHEPHERD
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  5. W. N. BELL
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THOMPSON, R., HEWETT, H., KILGORE, S. et al. Haemoglobin Variants in a Species of Wild Mice—Peromyscus maniculatus. Nature 210, 1063–1064 (1966). https://doi.org/10.1038/2101063a0

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