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Effects of Propiolactone on Rat Fibrocytes

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Abstract

B-PROPIOLACTONE has been reported1–4 to be a potent but slowly acting carcinogen in vivo. In an investigation of the effects of this agent on rat fibrocytes cultivated in vitro, treated cells were found to undergo a particular sequence of structural alterations which culminated in cytological malignancy. This sequence of changes appeared to be directly related to the process of carcinogenesis.

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Authors and Affiliations

  1. Department of Experimental Pathology, Mount Vernon Hospital and the Radium Institute, Northwood, Middlesex

    A. K. POWELL

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  1. A. K. POWELL
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POWELL, A. Effects of Propiolactone on Rat Fibrocytes. Nature 209, 77–78 (1966). https://doi.org/10.1038/209077a0

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