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Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation

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References

  1. Peery, T. M., and Miller, jun., F. N., in Pathology. A Dynamic Introduction to Medicine and Surgery, 10 (J. and A. Churchill, Ltd., London, 1961).

    Google Scholar 

  2. For refs. see Van Oettingen, W. F., The Halogenated Aliphatic, Olefinic, Cyclic, Aromatic and Aliphatic-aromatic Hydrocarbons, including the Halogenated Insecticides, their Toxicity and Potential Dangers (U. S. Govt. Printing Office, Washington, 1955).

    Google Scholar 

  3. Cameron, G. R., and Karunaratne, W. A. E., J. Path. Bact., 42, 1 (1936).

    Article  CAS  Google Scholar 

  4. Rees, K. R., in Cellular Injury (CIBA Symposium, J. and A. Churchill, Ltd., London, 1964).

    Google Scholar 

  5. Recknagel, R. O., and Lombardi, B., J. Biol. Chem., 236, 564 (1961). Heimberg, M., and Weinstein, I., Biochem. Pharm., 11, 163 (1962). Seakins, A., and Robinson, D. S., Biochem. J., 86, 401 (1963). Rees, K. R., and Shotlander, V. L., Proc. Roy. Soc., B., 157, 517 (1963).

    CAS  PubMed  Google Scholar 

  6. McCollister, D. D., Beamer, W. H., Atchison, G. J., and Spencer, M. C., J. Pharmacol., 102, 112 (1951). Paul, B. B., and Rubenstein, D., J. Pharmacol., 141, 141 (1963).

    CAS  Google Scholar 

  7. Butler, T. C., J. Pharmacol., 134, 311 (1961).

    CAS  Google Scholar 

  8. Reynolds, E. B., Fed. Proc., 22, 370 (1963).

    Google Scholar 

  9. Cottrell, T. L., in The Strengths of Chemical Bonds, second edit. (Butterworths, London, 1958).

    Google Scholar 

  10. Slater, T. F., Biochem. Pharm., 14, 178 (1965).

    Article  CAS  Google Scholar 

  11. Lester, D., and Greenberg, L. A., Arch. Indust. Hyg., 2, 335 (1950).

    CAS  Google Scholar 

  12. Glynn, L. E., in Cellular Injury, 118 (CIBA Symposium, J. and A. Churchill, Ltd., London, 1964).

    Google Scholar 

  13. Fassett, D. W., Ann. Rev. Pharmacol., 3, 267 (1963).

    Article  Google Scholar 

  14. Dixon, M., The Biochemical Reactions of Chemical Warfare Agents, Biochem. Soc. Symp. No. 2, 39 (1948).

  15. Brauer, R. W., Pesotti, R. L., and Pizzolato, P., Proc. Soc. Exp. Biol. and Med., 78, 174 (1951). Miller, L. L., Bly, C. G., Watson, M. L., and Bale, W. F., J. Exp. Med., 94, 431 (1951).

    Article  CAS  Google Scholar 

  16. Brauer, R. W., Leong, G. F., and Holloway, R. J., Amer, J. Physiol., 200, 548 (1961). Heimberg, M., Winstein, I., Dishman, E., and Dunkerley, A., J. Biol. Chem., 237, 3623 (1962). Heimberg, M., Watkins, M., and Tooker, R., J. Pharmacol., 145, 92 (1964).

    CAS  Google Scholar 

  17. Glynn, L. E., and Himsworth, H. P., Clin. Sci., 6, 235 (1948).

    CAS  PubMed  Google Scholar 

  18. Stoner, H. B., Brit. J. Exp. Path., 37, 176 (1956). Seneviratne, R. D., Quart. J. Exp. Physiol., 35, 77 (1949).

    CAS  PubMed  Google Scholar 

  19. Brauer, R. W., in The Biliary System, 101 (NATO Symposium, Newcastle, 1963).

    Google Scholar 

  20. Himsworth, H. P., in The Liver and its Diseases, 32 (Blackwell, Oxford, 1950). Goldschmidt, S., Ravdin, I. S., and Lucke, B., J. Pharmacol., 59, 1 (1937).

    Google Scholar 

  21. Brauer, R. W., Physiol. Revs., 43, 193 (1963).

    Google Scholar 

  22. Rogué, A. L., and Fèdorko, M. E., J. Histochem., 9, 613 (1961).

    Google Scholar 

  23. Schank, R. E., Morrison, G., Cheng, C. H., Karl, I., and Schwartz, R., J. Histochem., 7, 237 (1959). Schank, G. R., Karl, I. E., Brock, F. E., and Schank, R. E., Gastroenterol., 46, 302 (1964). Novikoff, A. B., J. Histochem. Cytochem., 7, 241 (1959).

    Google Scholar 

  24. Beinert, H., Sixth Intern. Congr. Biochem., New York, Abstr. Section 4, No. 23 (1964). Massey, V., and Gibson, Q. H., Fed. Proc., 23, 18 (1964).

    Google Scholar 

  25. Smuckler, E. A., Ph. D. Dissertation, Univ. Washington (1963). Baccino, F. M., Satta, G., and Mameli, L., Biochim. Biophys. Acta, 90, 606 (1964).

    Google Scholar 

  26. Bassi, M., Exp. Cell. Res., 20, 313 (1960).

    Article  CAS  Google Scholar 

  27. Smuckler, E. A., Iseri, O. A., and Benditt, E. P., J. Exp. Med., 116, 55 (1962). Smuckler, E. A., and Benditt, E. P., Science, 140, 308 (1963).

    Article  CAS  Google Scholar 

  28. Reynolds, E. S., J. Cell Biol., 19, 139 (1963).

    Article  CAS  Google Scholar 

  29. Rees, K. R. (personal communication). Neubert, D., and Maibauer, D., Arch. exp. Path. Pharmak., 235, 291 (1959).

    Google Scholar 

  30. Slater, T. F. (unpublished results); Biochem. J., 97, 22C (1965).

    CAS  Google Scholar 

  31. Recknagel, R. O., and Lombardi, B., J. Biol. Chem., 236, 564 (1961).

    CAS  PubMed  Google Scholar 

  32. Wigglesworth, J. S., J. Path. Bact., 87, 333 (1964).

    Article  CAS  Google Scholar 

  33. Levandoski, N. G., Baker, E. M., and Canham, J. E., Biochemistry, 3, 1465 (1964). Blume, E., Bannert, N., Kluge, J., and Frunder, H., Biochim. Biophys. Acta, 81, 590 (1964).

    Article  CAS  Google Scholar 

  34. Hochstein, P., and Ernster, L., Biochem. Biophys. Res. Comm., 12, 388 (1963). Hochstein, P., and Ernster, L., Cellular Injury (CIBA Symposium, J. and A. Churchill, London, 1964). Hochstein, P., and Ernster, L., Biochem. Biophys. Res. Comm., 14, 323 (1964).

    Google Scholar 

  35. Gallagher, C. H., Nature, 192, 881 (1961). Gallagher, C. H., Austral. J. Exp. Biol. and Med., Sci., 40, 241 (1962).

    Article  ADS  CAS  Google Scholar 

  36. Desai, I. D., Sawant, P. L., and Tappel, A. L., Biochim. Biophys. Acta, 86, 277 (1964).

    Article  CAS  Google Scholar 

  37. Slater, T. F., Greenbaum, A. L., and Wang, D. Y., in Lysosomes (CIBA Symposium, J. and A. Churchill, Ltd., London, 1963).

    Google Scholar 

  38. Artizzu, M., Pani, P., Satta, G., and Dianzani, M. U., Biochim. Biophys. Acta, 82, 454 (1964).

    Article  CAS  Google Scholar 

  39. Scaife, J. F., Canad. J. Biochem., 41, 1469 (1963).

    Article  CAS  Google Scholar 

  40. Slater, T. F., Strauli, U. D., and Sawyer, B. C., Biochem. J., 93, 260 (1964).

    Article  CAS  Google Scholar 

  41. Dawkins, M. J. R., J. Path. Bact., 85, 189 (1963).

    Article  CAS  Google Scholar 

  42. Drill, V. A., Pharmacol. Rev., 4, 1 (1952). Judah, J. D., and McLean, A. E. M., Intern. Rev. Exp. Path. (in the press).

    CAS  PubMed  Google Scholar 

  43. Larson, R. E., and Plaa, G. L., Experientia, 19, 604 (1963). Larson, R. E., and Plaa, G. L., J. Pharmacol., 147, 103 (1965). Poggi, M., and Paoletti, R., Biochem. Pharm., 13, 949 (1964).

    Article  CAS  Google Scholar 

  44. Bangham, A. D., Rees, K. R., and Shotlander, V. L., Nature, 193, 754 (1962).

    Article  ADS  CAS  Google Scholar 

  45. Rees, K. R., Sinha, K. P., and Spector, W. G., J. Path. Bact., 81, 107 (1961).

    Article  CAS  Google Scholar 

  46. Wollemann, M., Biochem. Pharm., 12, 757 (1963). Murphy, C. M., Ravner, H., and Smith, N. L., Ind. Eng. Chem., 42, 2479 (1950).

    Article  CAS  Google Scholar 

  47. Szent-Györgyi, A., Bioenergetics, 44 (Academic Press Inc., New York, 1957).

    Google Scholar 

  48. See Dawkins, M. J. R., Judah, J. D., and Rees, K. R., Biochem. J., 76, 200 (1960).

    Article  CAS  Google Scholar 

  49. Lessin, A. W., and Parkes, M. W., Brit. J. Pharmacol., 12, 245 (1957). Kollias, J., and Bullard, R. W., J. Pharmacol., 145, 373 (1964). Schuster, L., and Hannam, R. V., J. Biol. Chem., 239, 3401 (1964).

    CAS  PubMed  Google Scholar 

  50. Hoffsten, P. E., Hunter, jun., F. E., Gebicki, J. M., and Weinstein, J., Biochem. Biophys. Res. Comm., 7, 276 (1962).

    Article  CAS  Google Scholar 

  51. Desai, I. D., and Tappel, A. L., Lipid Res., 4, 204 (1963).

    CAS  Google Scholar 

  52. See Vasington, F. D., Reichard, S. M., and Nason, A., Vitamins and Hormones, 18, edit. by Harris, R. S., and Ingle, D. J. (Academic Press Inc., New York, 1960).

    Google Scholar 

  53. Reynolds, E. S., Fed. Proc., 24, Abstr. 213 (1965).

  54. Recknagel, R. O., and Ghoshal, A. K., Fed. Proc., 24, Abstr. 942 (1965).

    Google Scholar 

  55. See Ravdin, I. S., Vars, H. M., and Goldschmidt, S., J. Clin. Invest., 18, 633 (1939).

    Article  CAS  Google Scholar 

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  1. Department of Chemical Pathology, University College Hospital Medical School, London, W.C.1

    T. F. SLATER

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SLATER, T. Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation. Nature 209, 36–40 (1966). https://doi.org/10.1038/209036a0

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