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Stimulation of Sendai Virus Multiplication by Puromycin and Actinomycin D

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Abstract

THE rate of virus multiplication may ultimately be limited by the number of unprogrammed ribosomes available to viral nucleic acid. There is presumably only a finite probability in unit time that an infecting viral nucleic acid molecule can successfully compete with a vast excess of cellular messenger RNA molecules for an unoccupied ribosome. Even after attachment has been achieved, the subsequent rate of synthesis of viral constituents may be expected to depend on the availability of free ribosomes. This hypothesis was tested experimentally in cells pre-treated with two antibiotics, puromycin and actinomycin D, each capable of increasing the number of unprogrammed ribosomes.

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Authors and Affiliations

  1. School of Microbiology, University of Melbourne, Parkville, Victoria, Australia

    DAVID O. WHITE & IAN M. CHEYNE

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  1. DAVID O. WHITE
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  2. IAN M. CHEYNE
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WHITE, D., CHEYNE, I. Stimulation of Sendai Virus Multiplication by Puromycin and Actinomycin D. Nature 208, 813–814 (1965). https://doi.org/10.1038/208813a0

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