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Inhibition of Growth of Malignant Cells in vitro by a Component of Normal Adult Connective Tissue

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Abstract

NUMEROUS reports during the past 30 years support the thesis that biologically active factors present in normal adult tissue, growth-stimulating and growth-inhibiting substances, form a complex which regulates the growth of normal adult tissue. Upset of this balance may result in the unrestrained growth of cancer1–7. We have described the extraction by mild tryptic digestion of constituents of normal adult connective tissue (aorta, tendon, and skeletal muscle) which were growth-stimulating or growth-inhibitory to normal fibroblasts in tissue culture8. The effect on growth in vitro varied according to the conditions of extraction. Inhibitory extracts and crude precipitates from them further inhibited the growth in primary tissue culture of a series of human tumours from 75 to 100 per cent (refs. 9, 10).

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Authors and Affiliations

  1. Department of Surgery, and Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York City

    MARY STEARNS PARSHLEY & INES MANDL

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  1. MARY STEARNS PARSHLEY
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  2. INES MANDL
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PARSHLEY, M., MANDL, I. Inhibition of Growth of Malignant Cells in vitro by a Component of Normal Adult Connective Tissue. Nature 208, 800–801 (1965). https://doi.org/10.1038/208800a0

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