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Artificial Insemination of Dystrophic Mice with Mixtures of Spermatozoa

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Abstract

MUSCULAR dystrophy in mice (Dystrophia muscularis, symbol dy) is transmitted as an autosomal recessive1,2 and is linked to Steel (Sl) and Ames waltzer (av) in linkage group IV3–5. Mice of genotype dy/dy have pronounced weakness of the hind limbs and die as young adults. Dystrophic male mice do not breed, and dystrophic females may have one or sometimes two litters early in their reproductive life, when mated to normal males. The disease can be recognized in mice 2–3 weeks old and has a characteristic manifestation, described in detail by Michelson et al.1 and Loosli et al.6.

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References

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SOUTHARD, J., WOLFE, H. & RUSSELL, E. Artificial Insemination of Dystrophic Mice with Mixtures of Spermatozoa. Nature 208, 1126–1127 (1965). https://doi.org/10.1038/2081126b0

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