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Inhibition of Conjugation by Anti-inflammatory Drugs

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Abstract

IBUFENAC (4-isobutyl-phenylacetic acid) has recently been introduced as an anti-inflammatory drug. In animals it possesses analgesic, anti-inflammatory and antipyretic properties1. Thompson, Stephenson and Percy2 found raised serum transaminase-levels in 12 of 36 patients treated with ibufenac. Five cases of jaundice have now been recorded in about 400 patients receiving ibufenac2.

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References

  1. Adams, S. S., Cliffe, E. E., Lessel, B., and Nicholson, J. S., Nature, 200, 271 (1963).

    Article  ADS  CAS  Google Scholar 

  2. Thompson, M., Stephenson, P., and Percy, J. S., Ann. Rheum. Dis., 23, 397 (1964).

    Article  CAS  Google Scholar 

  3. Rechenberg, H. K. von, Phenylbutazone, second ed. (E. Arnold, Ltd. London, 1962).

    Google Scholar 

  4. Smetana, H. F., Ann. N.Y. Acad. Sci., 104, 821 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Weiner, M., Chenkin, T., and Burns, J. J., Amer. J. Med. Sci., 228, 36 (1954).

    Article  CAS  Google Scholar 

  6. Lathe, G. H., and Walker, M., Biochem. J., 70, 705 (1958).

    Article  CAS  Google Scholar 

  7. Levvy, G. A., and Storey, I. D. E., Biochem. J., 44, 295 (1949).

    Article  CAS  Google Scholar 

  8. Stevenson, I. H., and Dutton, G. J., Biochem. J., 82, 330 (1962).

    Article  CAS  Google Scholar 

  9. Markoff, N., Medizinische, 46, 2219 (1959).

    PubMed  Google Scholar 

  10. Schwartz, H. N., Marshall, D., and Robinson, B. D., N.Y. State J. Med., 54, 265 (1954).

    CAS  PubMed  Google Scholar 

  11. Whitehouse, M. W., Nature, 201, 629 (1964).

    Article  ADS  CAS  Google Scholar 

  12. Bassler, K. H., and Lang, K., Naunyn-Schmeideberg';s Arch. Exp. Path. Pharmak., 231, 254 (1956).

    Google Scholar 

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Authors and Affiliations

  1. Department of Chemical Pathology, St. George's Hospital Medical School, London, S.W.1

    T. HARGREAVES

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  1. T. HARGREAVES
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HARGREAVES, T. Inhibition of Conjugation by Anti-inflammatory Drugs. Nature 208, 1101–1102 (1965). https://doi.org/10.1038/2081101a0

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