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Anti-cerebroside Antibodies in Cerebrospinal Fluid of Rabbits with Experimental ‘Allergic’ Encephalomyelitis

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Abstract

IN the course of experimental ‘allergic’ encephalomyelitis (EAE), and after injection of brain emulsions, rabbits produce antibodies against cerebroside1–4. These anti bodies are demonstrable by the complement-fixation test as well as by the agar-gel precipitation test, when emulsions of cerebroside and the auxiliary lipids, cholesterol and lecithin (CCL), or emulsions of ethanolic extracts from spinal cord, are employed as antigens5. By ultracentri-fugation and immunoelectrophoresis we were able to identify these antibodies as γ1M (19S) and γ2 (7S) globulins6,7. The role of these antibodies in the pathogenesis of EAE is not at all clear8. It seemed of interest, therefore, to examine whether anti-cerebroside antibodies are also present in cerebrospinal fluid (CSF) of rabbits with EAE, and to ascertain to which variety of globulin they belong.

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Authors and Affiliations

  1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Germany

    ERNST KUWERT & BARBARA NIEDIECK

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  1. ERNST KUWERT
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  2. BARBARA NIEDIECK
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KUWERT, E., NIEDIECK, B. Anti-cerebroside Antibodies in Cerebrospinal Fluid of Rabbits with Experimental ‘Allergic’ Encephalomyelitis. Nature 207, 991–992 (1965). https://doi.org/10.1038/207991a0

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