Abstract
ALTHOUGH it has become generally accepted1 that epinephrine causes glycogenolysis in cardiac muscle by a series of enzymatic reactions involving the formation of cyclic AMP, activation of phosphorylase b kinase, and finally conversion of phosphorylase b to the active a form, direct evidence in favour of this mechanism in the intact heart is so far not conclusive2. Furthermore, a possible relation between cyclic AMP and the inotropic effect of catecholamines is also tentative.
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CHEUNG, W., WILLIAMSON, J. Kinetics of Cyclic Adenosine Monophosphate Changes in Rat Heart following Epinephrine Administration. Nature 207, 979–981 (1965). https://doi.org/10.1038/207979b0
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DOI: https://doi.org/10.1038/207979b0
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