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References
Martin, B. K., Nature, 207, 274 (1965).
Dayton, P. G., Yü, T. F., Chen, W., Berger, L., West, L. A., and Gutman, A. B., J. Pharm. Exp. Therap., 140, 278 (1963).
Boxer, G. E., Jelinek, V. C., Tompsett, R., DuBois, R., and Edison, A. O., J. Pharm. Exp. Therap., 92, 226 (1948).
Weiner, M., Shapiro, S., Axelrod, J., Cooper, J. R., and Brodie, B. B., J. Pharm. Exp. Therap., 99, 409 (1950).
Brodie, B. B., Weiner, M., Burns, J. J., Simpson, G., and Yale, E. K., J. Pharm. Exp. Therap., 106, 453 (1952).
Bedford, C., Cummings, A. J., and Martin, B. K., Brit. J. Pharmacol., 24, 418 (1965).
Cummings, A. J., and Martin, B. K., Nature, 200, 1296 (1963).
Swintosky, J. V., Nature, 179, 98 (1957).
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MARTIN, B. Kinetics of Elimination of Drugs Possessing High Affinity for the Plasma Proteins. Nature 207, 959–960 (1965). https://doi.org/10.1038/207959a0
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DOI: https://doi.org/10.1038/207959a0
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