Abstract
A PRELIMINARY communication from, this laboratory reported that feline Purkinje cells were excited by electrophoretically administered acetylcholine and carbaminocholine1. On the assumption that the presence of acetylcholinesterase in particular nerve fibres is indicative of their cholinergic nature2, and on the basis of the distribution of this enzyme in the cerebellum of the guinea-pig3, it was proposed that the sensitivity of Purkinje cells to cholinomimetics may be related to a transmitter function for acetylcholine at the parallel fibre—Purkinje cell dendrite synapses of the cat.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Crawford, J. M., Curtis, D. R., Voorhoeve, P. E., and Wilson, V. J., Nature, 200, 579 (1963).
Shute, C. C. D., and Lewis, P. R., Nature, 199, 1160 (1963).
Gerebtzoff, M. A., Cholinesterases (Pergamon Press, 1959).
Friede, R. L., and Fleming, L. M., J. Neurochem., 11, 1 (1964). Austin, L., Phillis, J. W., and Steele, R. P., Experientia, 20, 218 (1964). Kasa, P., Jóo, F., and Csillik, B., J. Neurochem. (in the press).
Shute, C. C. D., and Lewis, P. R., J. Anat., 98, 466 (1964); Nature, 205, 242 (1965).
Szentagothai, J., in Information Processing in the Nervous System, edit. by Gerard, R. W., and Duyff, J. W. (Excerpta Medica Found., 1964).
McCance, I., and Phillis, J. W., Experientia, 20, 217 (1964). McCance, I., and Phillis, J. W., Nature, 204, 844 (1964). Phillis, J. W., Brit. Med. Bull., 21, 26 (1965).
Eccles, J. C., Llinas, R., and Sasaki, K., Nature, 203, 245 (1964).
Crossland, J., and Mitchell, J. F., J. Physiol., 132, 391 (1956). Crossland, J., Garvin, J. D., and Mitchell, J. F., J. Physiol., 148, 20P (1959). Crossland, J., Woodruff, G. N., and Mitchell, J. F., Nature, 203, 1388 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CURTIS, D., CRAWFORD, J. Acetylcholine Sensitivity of Cerebellar Neurones. Nature 206, 516–517 (1965). https://doi.org/10.1038/206516a0
Issue Date:
DOI: https://doi.org/10.1038/206516a0
- Springer Nature Limited
This article is cited by
-
Development of neurons containing acetylcholinesterase and cholinacetyltransferase in dispersed cell culture of rat cerebellum
Histochemistry (1979)
-
Role of cholinergic structures in disturbances of cerebellar function during exposure to centripetal acceleration
Bulletin of Experimental Biology and Medicine (1972)
-
Acetylcholinesterase activity in certain glomeruli and Golgi cells of the granular layer of the rat cerebellar cortex
Zeitschrift f�r Anatomie und Entwicklungsgeschichte (1972)
-
Strychnine and Cortical Inhibition
Nature (1967)
-
Localization of acetylcholinesterase in the guinea pig cerebellar cortex
Acta Neurovegetativa (1967)