Abstract
RECENTLY 5-bromodeoxyuridine (BUDR) has been used extensively in irradiation investigations1–3, and its radiation-sensitizing action, together with its specific site of incorporation, has been used to support the contention that DNA is the primary site of radiation damage in cells4. BUDR alone affects chromosomal structure after prolonged treatment5, or at comparatively high concentrations6, but in less drastic and in a qualitatively different fashion than in cells irradiated with X-rays.
Similar content being viewed by others
References
Kaplan, H. S., Smith, K. C., and Tomlin, P. A., Rad. Res. 16, 98 (1962).
Stahl, F. W., Graseman, J. M., Oku, L., Fox, E., and Laird, C., Virology, 13, 98 (1961).
Djordjevic, B., and Szybalski, W., J. Exp. Med., 112, 503 (1960).
Opara-Kubinska Borowska, Z., and Szybalski, W., Biochem. Biophys. Acta 72, 298 (1963).
Hsu, T. C., and Somers, C. E., Proc. U.S. Nat. Acad. Sci., 47, 398 (1961).
Kaback, M. M., and Saksela, E., Exp. Cell Res., 34, 182 (1964).
Humphrey, R. M., Dewey, W. C., and Cork, A., Rad. Res., 19, 241 (1963).
Terasima, T., and Tolmach, L. J., Biophys. J., 3, 33 (1963).
Raskovic, D., Hajdukovic, S., and Karanovic, J., Nuclear Hematology, 2, 15 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DJORDJEVIC, B., DJORDJEVIC, O. Chromosomal Aberrations in Synchronized Mammalian Cells treated with 5-Bromodeoxyuridine and irradiated by Ultra-violet Light. Nature 206, 1165–1166 (1965). https://doi.org/10.1038/2061165a0
Issue Date:
DOI: https://doi.org/10.1038/2061165a0
- Springer Nature Limited