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Use of DEAE-‘Sephadex’ for the Fractionation of Allergic Serum

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Abstract

RECENTLY, Gelotte et al.1 have reported that chromatography on DEAE-‘Sephadex A-50’ of a 7S fraction of normal human serum resulted in the isolation of IgG (γSS) and IgA (γ1A) components which appeared to be free of other protein constituents. We have modified their procedure for the isolation of fractions containing skin-sensitizing activity from the sera of ragweed-sensitive individuals.

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References

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Authors and Affiliations

  1. Division of Immunochemistry and Allergy, Department of Experimental Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec

    L. GOODFRIEND, L. PERELMUTTER & B. ROSE

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  1. L. GOODFRIEND
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  2. L. PERELMUTTER
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  3. B. ROSE
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GOODFRIEND, L., PERELMUTTER, L. & ROSE, B. Use of DEAE-‘Sephadex’ for the Fractionation of Allergic Serum. Nature 205, 718–719 (1965). https://doi.org/10.1038/205718a0

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