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Evidence that Calcium activates the Contraction of Actomyosin by overcoming Substrate Inhibition

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Abstract

IT is believed that muscle contracts or relaxes depending on the concentration of calcium in the sarcoplasm: when the concentration rises to some required level the muscle contracts; when it falls below this level the muscle relaxes1–4. The sarcoplasmic reticulum, which can take up calcium actively, seems to play a major part in controlling the level of calcium available to the contractile protein5–7.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, New York University School of Medicine, New York, 16, New York

    HARVEY M. LEVY & ELIZABETH M. RYAN

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  1. HARVEY M. LEVY
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  2. ELIZABETH M. RYAN
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LEVY, H., RYAN, E. Evidence that Calcium activates the Contraction of Actomyosin by overcoming Substrate Inhibition. Nature 205, 703–705 (1965). https://doi.org/10.1038/205703b0

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