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Cholinesterase Catalysis

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Abstract

CHARACTERISTIC of all known schemes of esterase catalysis1–5 is the assumption that the reactive form of serine pre-exists in the enzyme molecule before the interaction of enzyme with substrate or inhibitor. This seems to be unlikely, for why this very reactive form is not involved in side-reactions is still very vague. Moreover, the possibility of the preliminary activation of serine aliphatic hydroxyl, by means of such a weak base as imidazole3–5, is not convincing.

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References

  1. Rydon, H. N., Nature, 182, 928 (1958).

    Article  ADS  CAS  Google Scholar 

  2. Bernhard, S. A., J. Cell. Comp. Physiol., 54, suppl. 1, 179 (1959).

    Article  Google Scholar 

  3. Cunningham, L. W., Science, 125, 1145 (1957).

    Article  ADS  CAS  Google Scholar 

  4. Spencer, T., and Sturtevant, J. M., J. Amer. Chem. Soc., 81, 1874 (1959).

    Article  CAS  Google Scholar 

  5. Krupka, R. M., and Laidler, K. J., J. Amer. Chem. Soc., 83, 1458 (1961).

    Article  CAS  Google Scholar 

  6. Koshland, jun., D. E., Adv. Enzymol., 22, 45 (1960).

    CAS  Google Scholar 

  7. Brestkin, A. P., Kabachnik, M. I., et al., Doklady Akademii Nauk S.S.S.R., 158, 880 (1964).

    CAS  Google Scholar 

  8. Rozengart, E. V., Biokhimia (in the press).

  9. Godovikov, N. N., et al., Doklady Akademii Nauk S.S.S.R., 151, 1104 (1963).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Setschenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of U.S.S.R., Leningrad

    A. P. BRESTKIN & E. V. ROZENGART

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  1. A. P. BRESTKIN
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  2. E. V. ROZENGART
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BRESTKIN, A., ROZENGART, E. Cholinesterase Catalysis. Nature 205, 388–389 (1965). https://doi.org/10.1038/205388a0

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