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Effect of Age and Hormonal State on the Numbers of Deoxyribonucleic Acid Synthesizing Nuclei in Rat Adrenal Cortex

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Abstract

THE use of tritiated thymidine to label nuclei synthesizing DNA (S-phase) prior to mitosis has provided much new information on the pattern and magnitude of cell turnover in many tissues and organs. Less is known, however, about the relative frequency of cell turn-over in the adrenal gland. Accordingly the investigation described here was undertaken to determine whether the number of nuclei in DNA synthesis in the different zones of the rat adrenal cortex varied with age and with experimental procedures designed to alter its hormonal environment.

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Authors and Affiliations

  1. Department of Pathology, University of Sheffield,

    H. P. R. BURY & W. A. J. CRANE

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  1. H. P. R. BURY
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  2. W. A. J. CRANE
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BURY, H., CRANE, W. Effect of Age and Hormonal State on the Numbers of Deoxyribonucleic Acid Synthesizing Nuclei in Rat Adrenal Cortex. Nature 205, 301–302 (1965). https://doi.org/10.1038/205301a0

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