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A New Molluscicide 1-(p-Nitrophenyl)-2-amidineurea Hydrochloride (T 72)

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Abstract

MOLLUSCICIDE Bayer 73 or 5,2-dichlor-4′-nitrosalicylanilide, better known as ‘BayluscidR’, has been shown to be a potent molluscicide1. The chemical similarity of T 72 to Bayer 73 (ref. 2) led us to investigate its possible molluscicide property. T 72 is known to be active against malaria3–6 and against several intestinal infestations7. It has the following structural formula:

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References

  1. Gonnert, R., and Schraufstetter, E., Trop. Med. Malaria, 2, 197 (1959).

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  2. Urbański, T., and Skowronska-Serafin, B., Bull. Acad. Polon. Sci., Cl. 3, 4, 361, 363 (1956).

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  3. Chin, Y., Wu, Y. Y., Skowronska-Serafin, B., Urbański, T., Venulet, J., and Jakimowska, K., Bull. Acad. Polon. Sci., Cl. 3, 8, 109 (1960).

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  5. Clyde, D. F., personal communication.

  6. W.H.O. Supplement to WHO/Mal/320, Nov. 1961, pp. 9–12

  7. Spawinski, J., Potaczek, T., Namirski, P., Urbański, T., and Serafin, B., Paper read at Int. Symp. Nitrocompounds, Warsaw, Sept., 1963.

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Authors and Affiliations

  1. Faculty of Medicine, University of Damascus, Damascus, Syria

    J. VENULET & G. O. SCHLUTZ

  2. Drug Research Institute, Warsaw, Poland

    J. VENULET

  3. Biological Chemistry Institute, Freiburg, Germany

    G. O. SCHLUTZ

Authors
  1. J. VENULET
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  2. G. O. SCHLUTZ
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VENULET, J., SCHLUTZ, G. A New Molluscicide 1-(p-Nitrophenyl)-2-amidineurea Hydrochloride (T 72). Nature 204, 900–901 (1964). https://doi.org/10.1038/204900a0

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