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A Selective Reagent for the Study of Base Sequence in Nucleic Acids

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Abstract

SOME time ago, we proposed an electron microscopic procedure for the determination of the sequence of bases in nucleic acids1. This method requires that electron-dense, base-specific groups be attached to the nucleic acid molecule. On examination in the electron microscope, the visible electron-dense groups indicate the positions of those bases to which they are specifically attached.

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References

  1. Beer, M., and Moudrianakis, E., Proc. U.S. Nat. Acad. Sci., 48, 409 (1962).

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Authors and Affiliations

  1. Departments of Biology and Biophysics, Johns Hopkins University, Baltimore, 18, Maryland

    EVANGELOS N. MOUDRIANAKIS & MICHAEL BEER

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  1. EVANGELOS N. MOUDRIANAKIS
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  2. MICHAEL BEER
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MOUDRIANAKIS, E., BEER, M. A Selective Reagent for the Study of Base Sequence in Nucleic Acids. Nature 204, 685–686 (1964). https://doi.org/10.1038/204685a0

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