Abstract
IN 1955 Wright et al.1 demonstrated that pimelic and azelaic acids stimulate the biosynthesis of biotin in Aspergillus niger. Since then, three groups2–4 of workers have established that pimelic acid is a precursor in the biosynthesis of biotin. It remained to be tested whether or not pimelic acid is a by-product of the microbial degradation of azelaic acid.
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References
Wright, L. D., Cresson, E. L., and Driscoll, C. A., Proc. Soc. Exp. Biol. and Med., N.Y., 89, 234 (1955).
Eisenberg, M. A., Biochem. Biophys. Res. Comm., 8, 437 (1962).
Elford, H. L., and Wright, L. D., Fed. Proc., 21, 467 (1962).
Lezius, A., Ringelmann, E., and Lynen, F., Biochem. Z., 336, 510 (1963).
Janota-Bassalik, L., and Wright, L. D., J. Gen. Microbiol. (in the press).
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JANOTA-BASSALIK, L., WRIGHT, L. Pimelic Acid as a By-product of Azelaic Acid Degradation by Pseudomonas sp.. Nature 204, 501–502 (1964). https://doi.org/10.1038/204501a0
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DOI: https://doi.org/10.1038/204501a0
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