Abstract
IN recent years dose-survival curves have been published for a number of mammalian cell lines in culture following X-irradiation, and it is often assumed that the extrapolation number (n) and the 37 per cent survival dose (D0) that characterize these curves are constants for a particular cell line. However, Lockart et al.1 noted small differences in n and D0 for different samples of HeLa S3 cells, and Bases2 found that of two strains of HeLa cells only one gave consistent values of n and D0. This communication describes variations in radiosensitivity with the phase of the growth cycle in rat sarcoma cells.
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References
Lockart, R. Z., Elkind, M. M., and Moses, W. B., J. Nat. Cancer Inst., 27, 1393 (1961).
Bases, R., Ann. N.Y. Acad. Sci., 95, 984 (1961).
Fischer, G. A. (private communication).
Ludovici, P. P., Pock, R. A., Christian, R. T., and Miller, N. F., Rad. Res., 14, 131 (1961).
Glinos, A. D., and North, H. H., Trans. N.Y. Acad. Sci., 26, 145 (1963).
Elkind, M. M., and Sutton, H., Rad. Res., 13, 556 (1960).
Salzman, N. P., Biochim. Biophys. Acta, 31, 158 (1959).
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MADOC-JONES, H. Variations in Radiosensitivity of a Mammalian Cell Line with Phase of the Growth Cycle. Nature 203, 983–984 (1964). https://doi.org/10.1038/203983a0
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DOI: https://doi.org/10.1038/203983a0
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