Skip to main content
SpringerLink
Log in

Structural Investigation of 4-[(4-Amino-5-pyrimidinyl)imino]-2-penten-2-ol

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

AS part of a continuing programme of synthesis of condensed pyrimidine ring systems as potential antimetabolites and antitumour agents, the preparation of the hitherto unreported 1,5-pyrimido[4,5-b]-diazepine ring system (I) was undertaken in these laboratories1. This ring system is analogous to the 1,5-benzodiazepines extensively examined by a number of investigators2–8. The preparation of the pyrimidodiazepines (I) was attempted by condensation of 4,5-diaminopyrimidine derivatives with β-diketones, as in the synthesis of the corresponding 1,5-benzodiazepines

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chatterjee, S., Trites, D. H., and Modest, E. J., Abstr. Papers, 136th Meeting, American Chemical Society, Atlantic City, New Jersey, 34-O (September 18, 1959).

  2. Thiele, J., and Steimmig, G., Ber., 40, 955 (1907).

    Article  CAS  Google Scholar 

  3. Finar, I. L., J. Chem. Soc., 4094 (1958).

  4. Barltrop, J. A., Richards, C. G., Russell, D. M., and Ryback, G., J. Chem. Soc., 1132 (1959).

  5. Barltrop, J. A., Richards, C. G., and Russell, D. M., J. Chem. Soc., 1423 (1959).

  6. Wigton, F. B., and Joullié, M. M., J. Amer. Chem. Soc., 81, 5212 (1959).

    Article  CAS  Google Scholar 

  7. Ried, W., and Draisbach, A., Chem. Ber., 92, 949 (1959).

    Article  CAS  Google Scholar 

  8. Halford, J. O., and Fitch, R. M., J. Amer. Chem. Soc., 85, 3354 (1963).

    Article  Google Scholar 

  9. Brown, D. J., in The Pyrimidines, edit. by Weissberger, A., 321–324 (Interscience, New York, 1962).

    Google Scholar 

  10. Jackman, L. M., Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry, 70 (Pergamon Press, The MacMillan Co., New York, 1959).

    Google Scholar 

  11. Yannoni, N. F., and Silverman, J., Nature, 202, 484 (1964).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Author notes

  1. SUPRABHAT CHATTERJEE

    Present address: Air Force Cambridge Research Laboratory, Hanscom Field, Bedford, Massachusetts

Authors and Affiliations

  1. Children's Cancer Research Foundation, and Department of Pathology, Harvard Medical School at Children's Hospital, Boston, Massachusetts

    SUPRABHAT CHATTERJEE, DOROTHY H. TRITES & EDWARD J. MODEST

Authors
  1. SUPRABHAT CHATTERJEE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. DOROTHY H. TRITES
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. EDWARD J. MODEST
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CHATTERJEE, S., TRITES, D. & MODEST, E. Structural Investigation of 4-[(4-Amino-5-pyrimidinyl)imino]-2-penten-2-ol. Nature 203, 970–971 (1964). https://doi.org/10.1038/203970a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/203970a0

  • Springer Nature Limited

This article is cited by

Search

Navigation