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Optical Rotatory Dispersion of Liver Alcohol Dehydrogenase and its Complexes

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Abstract

WE have recently reported that the stability of liver alcohol dehydrogenase (LADH) towards denaturing agents, such as heat, hydrogen or hydroxyl ions, is greatly enhanced in the binary complexes with NADH* or NAD, and still more in the ternary complexes with coenzymes and inhibitors1. The reaction velocity of the free SH groups with PCMS was greatly reduced by complex formation, and the solubility of the enzyme in phosphate buffer increased considerably.

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References

  1. Yonetani, T., and Theorell, H., Arch. Biochem. Biophys., 99, 433 (1962).

    Article  CAS  Google Scholar 

  2. Brändén, C. J., Larsson, L. M., Lindquist, I., Theorell, H., and Yonetani, T. (unpublished results).

  3. Dalziel, K., Acta Chem. Scand., 12, 459 (1958).

    Article  CAS  Google Scholar 

  4. Ulmer, D. D., Li, T. K., and Vallee, B. L., Proc. U.S. Nat. Acad. Sci., 47, 1155 (1961).

    Article  CAS  ADS  Google Scholar 

  5. Kauzmann, W., Ann. Rev. Phys. Chem., 8, 413 (1957).

    Article  CAS  ADS  Google Scholar 

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Authors and Affiliations

  1. Biokemiska Institutionen, Uppsala Universitet,

    ANDREAS ROSENBERG

  2. Medicinska Nobelinstitutet, Biokemiska Institutionen, Stockholm

    HUGO THEORELL & TAKASHI YONETANI

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  1. ANDREAS ROSENBERG
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  2. HUGO THEORELL
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  3. TAKASHI YONETANI
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ROSENBERG, A., THEORELL, H. & YONETANI, T. Optical Rotatory Dispersion of Liver Alcohol Dehydrogenase and its Complexes. Nature 203, 755–756 (1964). https://doi.org/10.1038/203755a0

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