A Difference in Susceptibility to Lymphoid Leukosis Virus and Rous Sarcoma Virus between Cells from Two Inbred Lines of Domestic Fowl

Abstract

GENETIC factors play an important part in the susceptibility of domestic fowl to lymphoid leukosis virus and Rous sarcoma virus (RSV)¹. Little is known, however, of the way in which traits for susceptibility or resistance to these viruses are translated in the fowl into differing responses to the viruses. Evidence that there may be a correlation between response to RSV and to other avian tumour viruses has been put forward by several workers^2,3. Many of the avian tumour viruses are closely related¹, and it might be expected therefore that resistance mechanisms would affect these viruses similarly. These present results support this correlation and indicate that a resistance mechanism exists which operates at the level of the individual cell.