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Localization of Spontaneous Lipid Deposition in the Cerebral Arteries of Sheep

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Abstract

LIPIDS in plasma and atherosclerotic plaques have been extensively investigated, and the sites of predilection for lipid deposition in hypercholesterolæmic rabbits are the intimal thickenings at bifurcations1. However, the precise location of early spontaneous lipid deposition in the arterial wall has not been determined. Therefore, an investigation was made of cerebral arterial forks in the sheep, a herbivorous animal with a low concentration of plasma lipids2, and serial, rather than random, sections were used to give a much more accurate localization of lipid and intimal thickening.

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Authors and Affiliations

  1. Department of Experimental Pathology, John Curtin School of Medical Research, Australian National University, Canberra

    W. E. STEHBENS

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  1. W. E. STEHBENS
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STEHBENS, W. Localization of Spontaneous Lipid Deposition in the Cerebral Arteries of Sheep. Nature 203, 1294–1295 (1964). https://doi.org/10.1038/2031294a0

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