Abstract
INVESTIGATIONS carried out by Helyer and Howie on a hybrid strain of mice derived by crossing the NZB/BL and NZW strains show that these animals died of renal failure within 8–10 months1. The renal lesions in these animals closely resembled those seen in human lupus nephritis. Using conventional microscopical techniques marked glomerular changes, including fibrinoid necrosis, thickening of the basement membrane and wire-loop formation were demonstrated.
Similar content being viewed by others
References
Helyer, B. J., and Howie, J. B., Nature, 197, 197 (1963).
Coons, A. H., General Cytochemical Methods, 1, edit. by Danielli, J. F., 399 (Academic Press, New York, 1958).
Riggs, J. L., Seiwald, R. J., Burckhalter, J. H., Downs, C. M., and Metcalf, T. G., Amer. J. Path., 34, 1081 (1958).
Marshall, J. D., Eveland, W. C., and Smith, C. W., Proc. Soc. Exp. Biol. and Med., 98, 898 (1958).
Chadwick, C. S., and Nairn, R. C., Immunology, 3, 363 (1960).
Coons, A. H., and Kaplan, M. H., J. Exp. Med., 91, 1 (1950).
Smith, C. W., Marshall, J. D., and Eveland, W. C., Proc. Soc. Exp. Biol. (N.Y.), 102, 179 (1959).
Nairn, R. C., Fluorescent Protein Tracing (E. and S. Livingstone, Ltd., Edinburgh and London, 1962).
Tan, E. M., and Kaplan, M. H., Immunology, 6, 331 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
AARONS, I. Renal Immunofluorescence in NZB/NZW Mice. Nature 203, 1080–1081 (1964). https://doi.org/10.1038/2031080a0
Issue Date:
DOI: https://doi.org/10.1038/2031080a0
- Springer Nature Limited
This article is cited by
-
Phenotypic and functional alterations of pDCs in lupus-prone mice
Scientific Reports (2016)
-
Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus
Seminars in Immunopathology (2014)
-
Circulating DNA and lupus nephritis
Kidney International (1988)
-
Renal Lesions in Young Adoptively Immunized NZB/BI Mice
Nature (1969)