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Chromosome Duplication and the Cell Cycle in Lens Epithelium

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Abstract

PREVIOUS experiments have shown that a penetrating needle injury to the central area of rabbit lens epithelium in vivo produces a response in which a large number of cells synthesize DNA and divide1. This response begins characteristically at the site of injury and progresses farther and farther away from the wound with time. Experiments have indicated that DNA synthesis is initiated in the cells closest to the wound at about 12–14 h after injury2. Mitosis is first seen at about 24 h after injury. The rate at which the wave of DNA synthesis travels was calculated to be about 17 µ/h. The typical picture obtained at 48 h after injury shows a band of cells which are synthesizing DNA and completely encircle the wound. Another band of mitotic figures is seen encircling the wound and lying between the DNA synthesis band and the injury but close to the DNA synthesis band. Frequently, when the injuries are larger (these can be obtained by using a larger needle) a ‘second wave’ of DNA synthesis and mitosis can be seen.

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References

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Author notes

  1. B. D. SRINIVASAN: Alfred P. Sloan Foundation Fellow of the College of Physicians and Surgeons.

Authors and Affiliations

  1. Department of Ophthalmology and the Subcommittee on Medical Cell Biology, Columbia University, College of Physicians and Surgeons, New York

    B. D. SRINIVASAN

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  1. B. D. SRINIVASAN
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SRINIVASAN, B. Chromosome Duplication and the Cell Cycle in Lens Epithelium. Nature 203, 100–101 (1964). https://doi.org/10.1038/203100b0

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