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Involution of Thymus and Suppression of Immune Responses in Rats treated with Reserpine

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Abstract

WE have observed that repeated injections of reserpine induce atrophy of the thymus in adult and new-born rats (unpublished results). Since the thymus is known to play an important part in immune reactions in mammals1,2, we thought it would be of interest to investigate the immunological capacity of reserpine-treated animals. This communication presents experimental evidence showing involution of the thymus and impairment of both delayed hypersensitive responses and antibody formation in adult rats treated with reserpine.

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References

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Authors and Affiliations

  1. Pharmacological and Microbiological Institutes, Faculty of Pharmacy,

    MIROSLAV DRAŠKOCI & BRANISLAV D. JANKOVIČ

  2. Immunology Unit, Institute of Biology, University of Belgrade, Yugoslavia

    MIROSLAV DRAŠKOCI & BRANISLAV D. JANKOVIČ

Authors
  1. MIROSLAV DRAŠKOCI
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  2. BRANISLAV D. JANKOVIČ
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DRAŠKOCI, M., JANKOVIČ, B. Involution of Thymus and Suppression of Immune Responses in Rats treated with Reserpine. Nature 202, 408–409 (1964). https://doi.org/10.1038/202408a0

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