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Diffusion Delay in Frog Skin Connective Tissue: a Source of Error in Tracer Investigations

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Abstract

PREVIOUS investigations of tracer kinetics across frog skin have assumed that the connective tissue layer of the corium does not present a significant diffusion barrier1,2. Thus, a simple analysis assuming a one-compartment model was used to estimate the sodium pool size and the fluxes across the epithelial cell borders. However, the present experiments indicate that the connective tissue layer is a significant diffusion barrier.

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References

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Authors and Affiliations

  1. Department of Physiology, Western Reserve University, School of Medicine, Cleveland, Ohio

    T. HOSHIKO & BARRY D. LINDLEY

  2. Department of Physiology, University of Minnesota, Minneapolis

    CHARLES EDWARDS

Authors
  1. T. HOSHIKO
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  2. BARRY D. LINDLEY
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  3. CHARLES EDWARDS
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HOSHIKO, T., LINDLEY, B. & EDWARDS, C. Diffusion Delay in Frog Skin Connective Tissue: a Source of Error in Tracer Investigations. Nature 201, 932–933 (1964). https://doi.org/10.1038/201932a0

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