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Formation of Ammonia from Glutamate by Mitochondria

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Abstract

AMMONIA is required for the synthesis of carbamyl phosphate and hence of urea; but its origin has remained obscure. It has been generally suggested1, 2 that it could arise from various amino-acids by trans-de-amination through glutamate: amino-acid + α-oxoglutarate → α-keto acid + glutamate glutamate + NAD(P) + H2O → α-oxoglutarate + NH3 + NAD(P)H2

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Authors and Affiliations

  1. Russell Grimwade School of Biochemistry and School of Agriculture, University of Melbourne, Parkville, N.2, Victoria, Australia

    F. J. R. HIRD & M. A. MARGINSON

Authors
  1. F. J. R. HIRD
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  2. M. A. MARGINSON
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HIRD, F., MARGINSON, M. Formation of Ammonia from Glutamate by Mitochondria. Nature 201, 1224–1225 (1964). https://doi.org/10.1038/2011224a0

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