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Further Observations on Differences in Eosinopenia between Inbred Strains of Mice

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Abstract

Thiessen and Nealey1 recently reported differences among five inbred strains of mice in behavioural reactivity and in adrenocortical activity, in response to taking blood counts and handling. On several measures, the C57BL/Crgl strain displayed greater sensitivity to the testing conditions than did other strains. Resting blood eosinophil-level was higher, test-retest reliability was higher and the correlation between resting-level and extent to which the second count differed from the initial count was greater. These findings corroborate the conclusion of Wragg and Speirs2 that the C57 genotype is maximally sensitive to measures of eosinopenic responses and, in addition, point out the value of the C57BL/Crgl strain for experimental purposes.

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References

  1. Thiessen, D. D., and Nealey, Vicki G., Endocrinol., 71, 267 (1962).

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  2. Wragg, L. E., and Speirs, R. S., Proc. Soc. Exp. Biol. Med., 80, 680 (1952).

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  3. Speirs, R. S., and Meyer, R. K., Endocrinol, 45, 403 (1949).

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Authors and Affiliations

  1. Department of Psychology, University of California, Berkeley, California

    V. G. NEALEY

  2. Section of Medical Psychology, Scripps Clinic and Research Foundation, La Jolla, California

    D. D. THIESSEN

Authors
  1. V. G. NEALEY
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  2. D. D. THIESSEN
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NEALEY, V., THIESSEN, D. Further Observations on Differences in Eosinopenia between Inbred Strains of Mice. Nature 201, 1055–1056 (1964). https://doi.org/10.1038/2011055b0

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